Evaluation of indirect sequence-specific magneto-extraction-aided LAMP for fluorescence and electrochemical SARS-CoV-2 nucleic acid detectionArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 변종, 치료기술, 치료제, [키워드] amplification approach circumvent clinically Disadvantages Electrochemical LAMP Host in silico inhibitor investigated isothermal isothermal amplification Magnetic sequence-specific target enrichment molecular NAAT nucleic acid Nucleic acid detection PCR polymerase probe qRT-PCR Quantitative Quantitative real-time LAMP real-time reverse transcriptase restrict SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 variant SARS-CoV-2. sensitivity sequence serum turn [DOI] 10.1016/j.talanta.2022.123809 PMC 바로가기
An efficient approach for SARS-CoV-2 monoclonal antibody production via modified mRNA-LNP immunizationArticle Published on 2022-11-052022-11-15 Journal: International journal of pharmaceutics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Antigen antigens applied approach approaches binding affinity circumvent complementary COVID-19 COVID-19 pandemic Delta Diseases evaluated functional fusion strategy generate immunization introduced lack Lipid Lipid nanoparticle (LNP) LNP mAb mAbs Membrane proteins methodology mice Modified mRNA monoclonal antibodies monoclonal antibody neutralize Neutralizing Neutralizing activity posttranslational modification Prophylactic Protein RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike SARS-CoV-2 virus SARS-CoV-2. serum serum antibody several variants therapeutic drug Treatment Vaccines variants [DOI] 10.1016/j.ijpharm.2022.122256 PMC 바로가기
Protein vaccine NVX-CoV2373 elicits functional T cell immunityArticle Published on 2022-10-032022-11-15 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 진단, [키워드] Analysis Antibody Response association CD4+ CD4+ T cell CD8+ T cell Cell characterized circumvent dose Effect elicit elicited enrolled follicular functional humoral immune responses Immunity individual induce mRNA vaccine neutralizing antibody titers NVX-CoV2373 recognizing Region response robust SARS-CoV-2 antigen SARS-CoV-2 vaccine T cell T cell responses Trial Vaccine vaccine dose [DOI] 10.1172/JCI163614 PMC 바로가기
Human coronaviruses: The emergence of SARS-CoV-2 and management of COVID-19Review article Published on 2022-10-012022-10-05 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료제, [키워드] acute respiratory syndrome circumvent coronavirus coronavirus disease COVID-19 Cross-species transmission deaths disease severity global pandemic Healthcare system highlight Human human coronavirus human coronaviruses implication Infection Long COVID management Mutation Respiratory pathogens SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Seven Strains transmission of SARS-CoV-2 Treatment Vaccines variants of concern zoonotic transmission [DOI] 10.1016/j.virusres.2022.198882 [Article Type] Review article
SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variantArticle Published on 2022-09-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] Activation analyzed antiviral response arising Beta Calu-3 cell calu-3 cells cellular circumvent comparable replication correlated COVID-19 infection Delta Effect epithelial Evolution genomic host cell human lung Immunity induce innate immune innate immune activation Innate immunity interferon interferon response ISG ISGs mRNA expression Mutation mutations omicron pandemic produced Replication replication efficiency SARS-CoV-2 SARS-CoV-2 variant signaling pathways STAT2 stimulated Transmission Treatment vaccination Vaccine variant variants variants of concern variants. variations Viral RNA virus virus replication while [DOI] 10.3389/fimmu.2022.1016108 PMC 바로가기
Technology-assisted adaptive recruitment strategy for a large nation-wide COVID-19 vaccine immunogenicity study in BruneiArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Public Health [Category] SARS, 진단, [키워드] adaptive adaptive recruitment Administered age analysed antibody AZD1222 BBIBP-CorV behavioural Brunei circumvent conducted Contact Contact tracing Coverage COVID-19 COVID-19 vaccine Data integration Digital digital technology dose Electronic health records electronic medical records eligible enrolled example Gender immune protection IMPROVE include individual information Intervention limitation Local media Mobile health MOST National neutralising antibodies (NAB). neutralising antibody outcome participant platform press random real time recruit recruitment Research SARS-CoV-2 SMS stratified Study participants survey platform technology time-consuming Vaccine Vaccines [DOI] 10.3389/fpubh.2022.983571 PMC 바로가기
Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion proteinRBD-뉴클레오캡시드 융합단백질을 이용한 관심대상 야생형 및 SARS-CoV-2 변이체에 대한 중화항체 비의존성 면역 촉진Article Published on 2022-08-172022-09-11 Journal: Nature Communications [Category] SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] ablated angiotensin antibody Antigen B cell B cells Blood CD4 CD8 chimeric circumvent Clinical outcome convertase COVID-19 convalescent donors COVID-19 vaccine COVID-19 vaccines Delta Depletion detectable effector T cell effector T cells elicit elicited experimental model experimental models fusion protein generate hamster IFN-γ Immune escape Immunity immunization IMPROVE inactivated indicated individual Infection infection with SARS-CoV-2 less lethality levels of antibody Lung inflammation mice NAbs Neutralizing Neutralizing antibodies neutralizing antibody nucleocapsid omicron promote promotion PROTECT Protein protocol protocols RBD RBD protein Receptor binding domain reduction robust SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 vaccine SARS-CoV-2 variant shown spike Spin T cell T cells transferred vaccination Vaccine variants variants of concern Viral Viral load virus wild type wild-type [DOI] 10.1038/s41467-022-32547-y PMC 바로가기 [Article Type] Article
Vaccines based on the replication-deficient simian adenoviral vector ChAdOx1: Standardized template with key considerations for a risk/benefit assessmentResearch article Published on 2022-08-012022-10-05 Journal: Vaccine [Category] COVID19(2023년), SARS, 비임상, [키워드] adenoviral vector Adenovirus administration Antigen approved assessment benefit Benefit/Risk booster capillary leak syndrome cell line Cellular immune response ChAdOx1 circumvent clinical evaluation clinical trial collaboration conducted COVID-19 COVID-19 vaccination Deletion dose effective Emergency use authorization evaluate evaluated expressing Extensive feature fevers Genetic Guillain-barrè syndrome Hemorrhagic HIV humoral immune response Immune thrombocytopenia impair Influenza key consideration malaria manuscript MERS-CoV New Nipah virus Oxford-AstraZeneca platform pre-existing immunity Prophylactic Prostate cancer Replication reported risk Safety SARS-CoV-2 Serious Adverse Event serotype surveillance data syndrome therapeutic thrombosis Tuberculosis University of Oxford Vaccine Vaccine development Vaccines vectored vaccine virus Zika [DOI] 10.1016/j.vaccine.2022.06.008 [Article Type] Research article
PCovNet: A presymptomatic COVID-19 detection framework using deep learning model using wearables dataPCovNet: 웨어러블 데이터를 사용하는 딥 러닝 모델을 사용하는 전증상 COVID-19 감지 프레임워크Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] abnormality Achille Administered Anomaly anomaly detection autoencoder average Chain Reaction circumvent contagious COVID-19 COVID-19 diagnosis COVID-19 infection COVID-19 pandemic dataset deep learning detect Diagnosis diagnostic evaluated feasibility framework healthcare heart heart rate individual Long Long short-term memory management protocol presymptomatic provoke Rate recall resting Resting heart rate Reverse transcription-polymerase chain reaction RT-PCR Secondary diagnosis Short-Term Memory smartwatch span Spread subject Symptom symptom onset Transmission Variational autoencoder. viral pathogen while [DOI] 10.1016/j.compbiomed.2022.105682 PMC 바로가기 [Article Type] Article
Inhalable dry powder mRNA vaccines based on extracellular vesiclesResearch article Published on 2022-07-112022-10-05 Journal: Matter [Category] 비임상, [키워드] Bioavailability Bronchiole carriers circumvent COVID-19 death disease distribution dry powder inhalation elicited exhibited Exosome Exosomes extracellular vesicle Extracellular vesicles functional greater IgG illness Immunoglobulin Inhaled limitation limitations Liposome lung mRNA mRNA vaccine NHPs nonhuman primate Protein remained respiratory Respiratory Coronavirus response rodent SARS-CoV-2 secretory IgA SIgA Spike protein stability Therapeutics Vaccine [DOI] 10.1016/j.matt.2022.06.012 [Article Type] Research article